HAZLET, N.J. - s4story -- In this educational initiative, HF expert faculty members will explain the evidence with
sMRAs in HFrEF, discuss the limitations associated with utilization of sMRA therapy,
describe the distinct profiles of sMRAs and nsMRAs, and interpret clinical evidence with
sMRAs and nsMRAs in HFmrEF and HFpEF. A case study will provide attendees with best
practices in overcoming challenges of diagnosing HFpEF, identify "pillars" of therapy, and
describe keys to their effective and safe implementation.

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CHAIR

Javed Butler, MD, MPH, MBA
President, Baylor Scott & White Research Institute
Dallas, Texas
Distinguished Professor of Medicine

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University of Mississippi
Jackson, Mississippi

FACULTY

Stephen Greene, MD
Associate Professor of Medicine
Duke University School of Medicine
Duke Clinical Research Institute
Durham, North Carolina

Muthiah Vaduganathan, MD, MPH
Co-Director, Center for Cardiometabolic Implementation Science
Assistant Professor of Medicine
Mass General Brigham and Harvard Medical School
Boston, Massachusetts

Orly Vardeny, PharmD, MS
Minneapolis VA Center for Care Delivery and Outcomes Research
Professor of Medicine
University of Minnesota
Minneapolis, Minnesota

Educational Objectives

• Describe the mechanisms of action of mineralocorticoid receptor antagonists (MRAs)
• Discuss the evidence for steroidal MRAs (sMRAs) in HFrEF and the challenges associated with their use
• Explain similarities and differences between nonsteroidal MRAs (nsMRAs) and sMRAs
• Interpret the clinical trial evidence for sMRAs and nsMRAs in patients with HFmrEF and HFpEF
• Indicate best practices for the diagnosis and treatment of patients with HFpEF

Target Audience

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This program is intended for clinicians who manage patients with heart failure.

Accreditation and Credit Designation Statements
Voxmedia, LLC is accredited by the Accreditation Council for
Continuing Medical Education (ACCME) to provide continuing
medical education for physicians.
Voxmedia, LLC designates this live activity for a maximum of
1.0 AMA PRA Category Credit(s)™. Physicians should claim
only the credit commensurate with the extent of their
participation in the activity.
Nurse practitioners may participate in this educational activity and earn a
certificate of completion as AANP accepts AMA PRA Category 1 Credits™
through its reciprocity agreements.
The National Commission on Certification of Physician Assistants accepts AMA
PRA Category 1 Credits™ from organizations accredited by the ACCME.