Popular on s4story
- Jasmine Farrell Releases New LGBTQ+ Poetry Collection - Rising From the Roots - 113
- Elevated Healing Treatment Centers: Redefining Mental Health Care with Compassionate, Evidence-Based, and Accessible Services - 112
- Venardi Zurada LLP Offers Legal Support to Families After Deadly Lake Tahoe Boat Capsizing - 112
- Keepy Uppy™ by Ollyball Wins Prestigious 2025 Influencer Award from Clamour & The Toy Association; Announces Fall 2025 Launch at Target Stores - 110
- K2 Integrity's U.S. and EMEA Teams Recognized in Chambers and Partners 2025 Guides - 109
- Lottery.com Inc. Secures $300 Million in Growth Capital, Confirms Nasdaq Compliance & Acquires UAE Sports Incubator Amid High-Profile Brand Exposure - 106
- Holiday Inn Express North Hollywood Burbank Area Announces Conversion to Hampton Inn North Hollywood - 106
- Anna D. Banks' Street Smart, Money Smart Hits #1 on Amazon Teen & Young Adult New Releases Chart
- Nationally Recognized Hispanic Activist and Businessman, Luis Figueroa, to speak at CPAC Latino 2025, Showcasing Hispanic Leadership in Action
- Don't Miss Your Chance To Be Part of History - Submit Your Book for the 2025 Grateful American Book Prize
Similar on s4story
- "Build Your Brand, Grow Your Business" Offers Entrepreneurs a Step-by-Step Blueprint for Success
- Pixel Studio Productions Launches Same-Day Headshots in Houston
- SeedList Launching Institutional Crypto Crowdfunding Project to Empower Retail Investors and Disrupt the VC-Dominated Crypto Fundraising Landscape
- Seligson Law Launches New Website to Support Cannabis Businesses in California and New York
- databahn Announces Subscription Access to Fortune 500 GenAI Deep Dive Sales Intelligence Reports
- AI startup Congero offers instant websites with 24/7 updates - aiming to replace web agencies
- WonderDays Launches the UK's First AI Experience Gift Finder – Gifting Just Got So Much Easier!
- Nonprofit innovator named Mensa Executive Director
- Yasmine Roulleau named Managing Director in Vancouver, Canada
- Agreement to Deliver Thin-Film Solar Technology to Space Solar Array Provider, NASA Collaborative Agreement for Orbital Applications in Power Beaming
Children's Hospital of Philadelphia Researchers Lead First Study to Identify Molecular Basis of Food Allergy
S For Story/10649734
PHILADELPHIA, Feb. 4, 2025 ~ A groundbreaking study led by researchers at Children's Hospital of Philadelphia (CHOP) has identified one of the allergens responsible for eosinophilic esophagitis (EoE), a chronic inflammatory disease of the esophagus. Published in the Journal of Allergy and Clinical Immunology, this is the first time that one of the allergens causing EoE has been identified at a molecular level.
EoE, a food allergy that affects approximately 1 in every 2000 children, was unknown until about 30 years ago. Unlike other food allergies, EoE is one that children do not outgrow. Instead of being triggered by a specific type of food, multiple foods such as milk, soy, egg, and wheat can cause EoE. Additionally, what may trigger this allergic response in one child may be different in another.
While some medications are available to manage allergic symptoms like immunosuppressants, they are not always effective for all patients. If left untreated and the triggering food is not removed from the diet, EoE can lead to scar tissue in the esophagus and put patients at risk for food impaction.
More on S For Story
The senior study author Dr. David A. Hill, an attending physician with CHOP's Division of Allergy and Immunology, explained the goal of this project: "The overarching goal of this project was to identify how the immune system is recognizing food antigens." He added that understanding this process at a molecular level could lead to better diagnostic tests and ultimately reduce the morbidity associated with EoE.
To achieve this goal, the research team used various sequencing methods including single cell RNA sequencing, T-cell receptor sequencing, and tetramer-based diagnostics. Tetramer-based diagnostics are typically used for certain types of cancer and utilize four major histocompatibility complex (MHC) molecules found on most cells in the body to identify antigen-specific T cells. This helps identify the specific antigens that trigger the immune response.
Using these methods, the researchers were able to pinpoint the exact milk protein – β-casein AA 59-78 – that caused EoE in one patient. This patient had a known allergy to milk, and the sequencing methods were able to confirm that this specific protein was responsible for their case of EoE.
More on S For Story
Dr. Hill emphasized that this study required collaboration and expertise from across the country, as well as advanced technology and understanding of the disease process. He also noted that while this study focused on one patient with EoE triggered by milk, their findings have broader implications and they plan to expand their research to other foods that may trigger allergic responses.
The study was supported by various grants and funds from organizations such as the American Partnership for Eosinophilic Disorders, American Academy of Allergy, Asthma, and Immunology, Food Allergy Fund, The Hartwell Foundation, Yehudai Family Foundation, and Children's Hospital of Philadelphia Endowed Chair in Genomic Research.
This groundbreaking research provides a molecular basis for understanding how food allergens are recognized in EoE. The team's findings could lead to improved diagnostic tests and potentially more effective treatments for this increasingly common childhood condition. The full study can be found online in the Journal of Allergy and Clinical Immunology with a DOI of 10.1016/j.jaci.2025.01.008.
EoE, a food allergy that affects approximately 1 in every 2000 children, was unknown until about 30 years ago. Unlike other food allergies, EoE is one that children do not outgrow. Instead of being triggered by a specific type of food, multiple foods such as milk, soy, egg, and wheat can cause EoE. Additionally, what may trigger this allergic response in one child may be different in another.
While some medications are available to manage allergic symptoms like immunosuppressants, they are not always effective for all patients. If left untreated and the triggering food is not removed from the diet, EoE can lead to scar tissue in the esophagus and put patients at risk for food impaction.
More on S For Story
- Chilling Sequel to Popular Children's Horror Series Launches August 1st
- SeedList Launching Institutional Crypto Crowdfunding Project to Empower Retail Investors and Disrupt the VC-Dominated Crypto Fundraising Landscape
- Injured Goose Finds Flight in Heartwarming New Children's Book
- California Family Launches Billboard to Reach "Pardon Czar" Alice Marie Johnson
- Global Anthology Project Seeks Writers to Share Stories of Healing After Loss
The senior study author Dr. David A. Hill, an attending physician with CHOP's Division of Allergy and Immunology, explained the goal of this project: "The overarching goal of this project was to identify how the immune system is recognizing food antigens." He added that understanding this process at a molecular level could lead to better diagnostic tests and ultimately reduce the morbidity associated with EoE.
To achieve this goal, the research team used various sequencing methods including single cell RNA sequencing, T-cell receptor sequencing, and tetramer-based diagnostics. Tetramer-based diagnostics are typically used for certain types of cancer and utilize four major histocompatibility complex (MHC) molecules found on most cells in the body to identify antigen-specific T cells. This helps identify the specific antigens that trigger the immune response.
Using these methods, the researchers were able to pinpoint the exact milk protein – β-casein AA 59-78 – that caused EoE in one patient. This patient had a known allergy to milk, and the sequencing methods were able to confirm that this specific protein was responsible for their case of EoE.
More on S For Story
- TheMindologist Returns with Bold New Release
- Rent Like A Champion Acquires CollegeWeekends
- Sumter Landing Dental Care Launches Summer Special on Full Mouth Reconstruction
- Seligson Law Launches New Website to Support Cannabis Businesses in California and New York
- databahn Announces Subscription Access to Fortune 500 GenAI Deep Dive Sales Intelligence Reports
Dr. Hill emphasized that this study required collaboration and expertise from across the country, as well as advanced technology and understanding of the disease process. He also noted that while this study focused on one patient with EoE triggered by milk, their findings have broader implications and they plan to expand their research to other foods that may trigger allergic responses.
The study was supported by various grants and funds from organizations such as the American Partnership for Eosinophilic Disorders, American Academy of Allergy, Asthma, and Immunology, Food Allergy Fund, The Hartwell Foundation, Yehudai Family Foundation, and Children's Hospital of Philadelphia Endowed Chair in Genomic Research.
This groundbreaking research provides a molecular basis for understanding how food allergens are recognized in EoE. The team's findings could lead to improved diagnostic tests and potentially more effective treatments for this increasingly common childhood condition. The full study can be found online in the Journal of Allergy and Clinical Immunology with a DOI of 10.1016/j.jaci.2025.01.008.
Filed Under: Business
0 Comments
Latest on S For Story
- Josh & Heidi Share Upcoming "Spreading the Good BUZZ" Podcast Guests, Select Top Five Elopement Locations as Their Instagram Presence Grows Globally
- Opteamix Launches StackRewrite.AI to Transform Enterprise Legacy Modernization
- Kilpack's Crown Prince Breaks Out at Outstanding Creator Awards
- "The Pornified Generation": Dr. Chris Samuels Exposes the Toxic Alliance Between Bro Culture and Pornography That's Rewiring a Generation
- Why Elephants Cry and Pigs Sing: New Children's Book Reveals the Deep Emotional World of Animals in Stunning Verse
- 6-Year-Old Chef with Down Syndrome Shares Favorite Recipes in Uplifting New Cookbook
- Cook Throughout German History!
- The Modern Insurance Store Expands Medicare Help Services for Seniors in Cincinnati
- Ironside HR Named Fastest-Growing Staffing Firm for Second Year
- Inframark Continues to Build Its Community Management Capabilities and Multi-Disciplinary Presence in Arizona
- ICAST 2025: The Crystal-Clear Revolution Begins at Booth #3233
- Brindle Pet Supplies Now Carries Badlands Ranch Dog Food in Canada
- $10 Million Allocated to Establish Crypto Treasury Focused on High Value Ethereum (ETH) & Bitcoin (BTC) as Long-Term Holdings for Cybersecurity Leader
- Sing For Your Supper: A Night of Musical Comedy and Drag for a Great Cause
- Cummings Graduate Institute for Behavioral Health Studies Celebrates New DBH Graduates
- $100 to $200 Million Equity Agreement with Top Digital Advisor Bitwise to Power Major Digital Asset Initiative for Bitcoin and Solana: OFA Group
- New Collaboration Launches Corporate ESG Solution for Responsible Decommissioning and Transparent Reporting
- SlickCashLoan Launches Free Loan Calculator to Help You Plan Monthly Payments
- Hot New Fantasy Series Alert: The Key to Wonderland Captivates Readers with Dark Magic and Twisted Romance
- TikTok Star ArcadeFriends Attempts 24-Hour Claw Machine Marathon at Lucky Puppy Arcade in Las Vegas